Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1206
Protein Name
Aquaporin Z
Gene Name
aqpZ; VP2176
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Length
232 amino acids
AlphaFoldDB
AF-Q87MQ5-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MNKYLAEAFGTFWLVLGGCGSAVLAAGFPDVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVTVGLWAGGRFDTKDVAPYIIAQVIGGLIAGGILYVIATGQAGFDVVGSGFAANGYGEHSPGQYSMLAALVSEIVMTMMFLIVIMGATDKRAPQGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTAVAMYVGDWAVSQLWLFWVAPIVGGVLGAVIYKNLLGKESND
PDB Structures
Ligand Binding
Binding Site
SITE 19: "Involved in tetramerization or stability of the tetramer"; SITE 42: "Selectivity filter"; SITE 173: "Selectivity filter"; SITE 182: "Selectivity filter"; SITE 188: "Selectivity filter"
Disease
Location
DOI ID
10.1016/s0140-6736(03)12659-1
RefSeq
NP_798555.1; WP_005460095.1